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Abstract We address the question of how to use a machine learned (ML) parameterization in a general circulation model (GCM), and assess its performance both computationally and physically. We take one particular ML parameterization (Guillaumin & Zanna, 2021,https://doi.org/10.1002/essoar.10506419.1) and evaluate the online performance in a different model from which it was previously tested. This parameterization is a deep convolutional network that predicts parameters for a stochastic model of subgrid momentum forcing by mesoscale eddies. We treat the parameterization as we would a conventional parameterization once implemented in the numerical model. This includes trying the parameterization in a different flow regime from that in which it was trained, at different spatial resolutions, and with other differences, all to test generalization. We assess whether tuning is possible, which is a common practice in GCM development. We find the parameterization, without modification or special treatment, to be stable and that the action of the parameterization to be diminishing as spatial resolution is refined. We also find some limitations of the machine learning model in implementation: (a) tuning of the outputs from the parameterization at various depths is necessary; (b) the forcing near boundaries is not predicted as well as in the open ocean; (c) the cost of the parameterization is prohibitively high on central processing units. We discuss these limitations, present some solutions to problems, and conclude that this particular ML parameterization does inject energy, and improve backscatter, as intended but it might need further refinement before we can use it in production mode in contemporary climate models. 

PurposeTo improve the performance of neural networks for parameter estimation in quantitative MRI, in particular when the noise propagation varies throughout the space of biophysical parameters. Theory and MethodsA theoretically well‐founded loss function is proposed that normalizes the squared error of each estimate with respective Cramér–Rao bound (CRB)—a theoretical lower bound for the variance of an unbiased estimator. This avoids a dominance of hard‐to‐estimate parameters and areas in parameter space, which are often of little interest. The normalization with corresponding CRB balances the large errors of fundamentally more noisy estimates and the small errors of fundamentally less noisy estimates, allowing the network to better learn to estimate the latter. Further, proposed loss function provides an absolute evaluation metric for performance: A network has an average loss of 1 if it is a maximally efficient unbiased estimator, which can be considered the ideal performance. The performance gain with proposed loss function is demonstrated at the example of an eight‐parameter magnetization transfer model that is fitted to phantom and in vivo data. ResultsNetworks trained with proposed loss function perform close to optimal, that is, their loss converges to approximately 1, and their performance is superior to networks trained with the standard mean‐squared error (MSE). The proposed loss function reduces the bias of the estimates compared to the MSE loss, and improves the match of the noise variance to the CRB. This performance gain translates to in vivo maps that align better with the literature. ConclusionNormalizing the squared error with the CRB during the training of neural networks improves their performance in estimating biophysical parameters.